The 10 Most Common Sexually transmitted diseases (STDs) in the U.S.: Symptoms, Testing, and How to Protect Your Health

An informative guide on the 10 most common STDs in the U.S., covering symptoms, testing options, and treatment methods.
 Learn how to protect your sexual health and prevent infections with expert insights and up-to-date statistics.
Explore symptoms, testing, and treatment for the 10 most common STDs. Photo Credit: Getty Image

Sexually transmitted diseases (STDs) remain a critical public health challenge in the United States, affecting millions annually. Despite advancements in medicine and education, many infections go undiagnosed due to stigma, lack of symptoms, or limited access to testing. This article breaks down the 10 most common STDs in the U.S., offering clear insights into their symptoms, testing methods, and treatment options. Let’s dive in.

1. Chlamydia

Symptoms: Often called a “silent infection,” chlamydia frequently shows no symptoms. When present, symptoms may include painful urination, abnormal genital discharge, or pelvic pain (in women).
Testing: A simple urine test or swab of the affected area (vagina, cervix, urethra, or rectum) can detect the bacteria.
Treatment: Curable with antibiotics like azithromycin or doxycycline. The CDC reported over 1.6 million cases in 2022, making it the most common bacterial STD. Untreated chlamydia can lead to pelvic inflammatory disease (PID) or infertility.

2. Gonorrhea

Symptoms: Similar to chlamydia, gonorrhea may cause painful urination, discharge, or sore throat (from oral sex). Many cases are asymptomatic.
Testing: Urine tests or swabs are used for diagnosis.
Treatment: Antibiotic-resistant strains are rising, but the CDC recommends a single shot of ceftriaxone. Co-infection with chlamydia is common, so dual testing is crucial. Over 700,000 cases were reported in 2022.

3. Syphilis

Symptoms: Progresses in stages:

  • Primary: Painless sores (chancres) at infection sites.
  • Secondary: Rash, fever, swollen lymph nodes.
  • Latent/Tertiary: Organ damage, neurological issues.
    Testing: Blood tests or swabs of sores.
    Treatment: A penicillin injection cures early stages. Congenital syphilis (passed to babies during pregnancy) has surged, with 207,000 total cases reported in 2022.

4. Human Papillomavirus (HPV)

Symptoms: Many strains cause no symptoms, but some lead to genital warts or cancers (cervical, throat).
Testing: Pap smears or HPV-specific tests for cervical changes. No test exists for throat or male genital HPV.
Treatment: No cure, but vaccines (Gardasil 9) prevent high-risk strains. Over 43 million Americans have HPV, emphasizing the importance of vaccination.

5. Herpes (HSV-1 and HSV-2)

Symptoms: Painful blisters or sores around the mouth (HSV-1) or genitals (HSV-2). Many carriers are asymptomatic.
Testing: Swabs of active sores or blood tests for antibodies.
Treatment: Antivirals like acyclovir reduce outbreaks and transmission risk. Roughly 1 in 6 adults has HSV-2, while HSV-1 (often oral) affects over 50% of adults.

6. Trichomoniasis

Symptoms: Itching, burning, or frothy discharge (more noticeable in women). Men may experience urethral irritation.
Testing: Swab or urine sample examined under a microscope.
Treatment: A single dose of metronidazole or tinidazole cures this parasite. The CDC estimates 2.6 million infections annually, though many go unreported.

7. HIV

Symptoms: Early flu-like symptoms (fever, fatigue), followed by a latent phase. Without treatment, HIV progresses to AIDS.
Testing: Blood or oral fluid tests detect antibodies or viral load.
Treatment: Antiretroviral therapy (ART) suppresses the virus, allowing individuals to live healthy lives. Pre-exposure prophylaxis (PrEP) pills or injections prevent infection. About 34,000 new cases occurred in 2022.

8. Hepatitis B

Symptoms: Jaundice, fatigue, abdominal pain. Some develop chronic liver disease.
Testing: Blood tests check for viral antigens/antibodies.
Treatment: Vaccination prevents infection. Chronic cases are managed with antivirals like tenofovir. Sexual transmission accounts for 23% of acute cases in the U.S.

9. Hepatitis C

Symptoms: Often asymptomatic until liver damage occurs.
Testing: Blood tests screen for antibodies and viral RNA.
Treatment: Direct-acting antivirals (DAAs) cure over 95% of cases. Though primarily spread through blood, sexual transmission is possible, especially among HIV-positive individuals.

10. Mycoplasma Genitalium

Symptoms: Similar to chlamydia: urethritis, pelvic pain, or discharge.
Testing: Nucleic acid amplification tests (NAATs) detect this emerging bacterial infection.
Treatment: Antibiotics like moxifloxacin, as resistance to azithromycin is rising. Though not yet nationally reportable, studies suggest it’s as common as gonorrhea.

FAQs About STDs

Q: Can STDs be cured?
A: Bacterial and parasitic STDs (chlamydia, gonorrhea, syphilis, trichomoniasis) are curable. Viral STDs (HIV, herpes, HPV) are manageable but not curable.

Q: How often should I get tested?
A: Annual testing for sexually active individuals. Those with multiple partners or higher risk (e.g., men who have sex with men) may need testing every 3–6 months.

Q: Can you get an STD from oral sex?
A: Yes. Gonorrhea, syphilis, HSV-1, and HPV can spread through oral-genital contact.

Q: Do condoms prevent all STDs?
A: Condoms reduce risk but don’t eliminate it. Skin-to-skin infections (herpes, HPV) can spread via uncovered areas.

Q: What if I test positive?
A: Notify partners, follow treatment guidelines, and retest as advised. Many STDs are easily treated, and early action prevents complications.

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